Evaluating the Effect of Lignocellulose-Derived Microbial Inhibitors on the Growth and Lactic Acid Production by Bacillus coagulans Azu-10

Effective lactic acid (LA) production from lignocellulosic biomass materials is challenged by several limitations related to pentose sugar utilization, inhibitory compounds, and/or fermentation conditions. In this study, a newly isolated Bacillus coagulans strain Azu-10 was obtained and showed homofermentative LA xylose with optimal conditions at 50 °C pH 7.0. Growth of LA-fermentation efficiency were evaluated in the presence various lignocellulose-derived inhibitors (furans, carboxylic acids, phenols) different concentrations. Furanic lignocellulosic-derived completely detoxified. The has exhibited high biomass, complete consumption, 1.0–4.0 g/L furfural 1.0–5.0 hydroxymethyl furfural, separately. Moreover, 5.0–15.0 acetic acid, 5.0 formic up 7.0 levulinic Besides, for phenolic p-coumaric most toxic 1.0 g/L, while syringaldehyde or p-hydroxybenzaldehyde, vanillin did not inhibit fermentation. present study provides an interesting potential candidate thermophilic substrates industrial biorefinery level.